Decreased Na+/K+ ATPase α1 (ATP1A1) gene
expression in major depression patients’peripheral blood
重症憂鬱症患者外周血中Na+/K+ ATPaseα1(ATP1A1)基因表達降低
Diseases associated with ATP1A1 include Charcot-Marie-Tooth Disease, Axonal,
Type 2Dd and Hypomagnesemia, Seizures, And Mental Retardation 2.
與ATP1A1相關的疾病包括低鎂血症,癲癇發作和精神發育遲滯2。
Among its related pathways are Development_Leptin signaling via PI3K-dependent pathway
and cAMP signaling pathway.
其相關途徑包括通過PI3K依賴性途徑和cAMP信號傳導途徑進行的Development_Leptin信號傳導。
Cellular cAMP concentration
is modulated by adenylyl cyclases (ACs), a family of enzymes that are strongly
activated by intracellular magnesium
細胞cAMP濃度由腺苷酸環化酶(ACs)調節,腺苷酸環化酶是一類由細胞內鎂強烈激活的酶
Magnesium Ions Promote the Biological Behaviour of Rat Calvarial Osteoblasts
by Activating the PI3K/Akt Signalling Pathway.
鎂離子激活PI3K / Akt信號通路
小結1:
由以上可知,憂鬱症主要缺鎂,鋅也有幫助。
三、
Increased NR2A:NR2B ratio compresses long-term depression range and constrains
long-term memory.
NR2A:NR2B比值的增加會壓縮長期憂鬱的範圍。
壓縮長期憂鬱的範圍,憂鬱範圍變小,憂鬱程度降低。
~~~
In conclusion, glutamate NMDA receptor NR2B subunit was involved in promoting
depression-like behaviours in the Licl-pilocarpine chronic rat epilepsy model
and might be a target for treating epilepsy-associated depression.
總之,谷氨酸NMDA受體NR2B亞基參與促進Licl-pilocarpine慢性大鼠癲癇模型中的憂鬱樣行為,
並且可能是治療與癲癇相關的憂鬱症的靶標。
毒癮、各種癮,怎麼戒?Part-III(建議補充鎂+鋅+錳,可以喝桂格完膳、豆漿、茶)
鋅和鎂增加NR2A表達,降低NR2B表達(錳會降低NR2A也會降低NR2B)
NR2B受體亞基的過表達導致口吃
Figure 1.
圖1.
C) The water channel marker, AQP4 protein levels is found to reduce in depression.
C)發現在憂鬱症中水通道標誌物AQP4蛋白水平降低。
錳(Mn)提升了水通道蛋白AQP-4(aquaporin-4)的膜表達
小結2:
由以上可知,憂鬱症主要缺鎂鋅,錳也有幫助。
總結以上: